Endothelial Dysfunction: Cardiovascular Risk Factors, Therapy, and Outcome

Biomarkers of endothelial dysfunction, cardiovascular risk factors and atherosclerosis in rheumatoid arthritis

Cardiovascular event rates are markedly increased in rheumatoid arthritis (RA), and RA atherogenesis remains poorly understood. The relative contributions of traditional and nontraditional risk factors to cardiovascular disease in RA await elucidation. The present study comprises three components. First, we compared biomarkers of endothelial dysfunction (vascular cell adhesion molecule [VCAM]-1...

Endothelial fibrinolytic function in hypertension: the expanding story.

In recent years, impairment of endothelial function has been a major focus of clinical research into cardiovascular disease. Endothelial dysfunction is associated with classical risk factors and there is accumulating evidence that it also independently predicts cardiovascular outcome [1]. This research has almost exclusively focused on endothelium-dependent vasodilatation as a measure of endoth...

Endothelial Progenitor Cell Dysfunction in Polycystic Ovary Syndrome: Implications for The Genesis of Cardiovascular Diseases

Endothelial dysfunction—An important factor in the progression of atherosclerosis in HIV-infected persons

The antiretroviral therapy has remarkably modified the process of HIV disease, enhancing higher quality of life and longer survival, however it has contemporaneously lead to the occurrence of earlier unrecognized complications, such as endothelial dysfunction and cardiovascular events. The endothelial dysfunction is directly caused by HIV-induced endothelial cell death (effects on metabolism, i...

Novel functional risk factors for the prediction of cardiovascular events in vulnerable patients following acute coronary syndrome.

Over the years there has been considerable improvement in the clinical outcomes of patients treated for acute coronary syndrome (ACS). Despite a significant reduction in acute mortality, a large percentage of patients post ACS continue to experience adverse cardiovascular (CV) events, with high long-term mortality rates and overall suboptimal medical management. Long-term risk prediction tools ...